CHEMO-HYDRO-MECHANICAL COUPLING IN ANNULUS FIBROSUS TISSUE
نویسندگان
چکیده
منابع مشابه
Biphasic scaffold for annulus fibrosus tissue regeneration.
Intervertebral disc (IVD) degeneration is the major cause of lower back pain, while the currently available treatments are symptomatic rather than curative. Tissue engineering is a powerful therapeutic strategy that can restore the normal biomechanical motion of the human spine. The ability of a biphasic elastic scaffold to structurally and elastically simulate the annulus fibrosus (AF) tissue ...
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INTRODUCTION Intervertebral disc (IVD) tissue engineering has been the focus of much recent interest. In particular, several groups [1,2] have attempted to reconstruct an intact IVD for transplant. A significant challenge in this effort has been mimicking the aligned collagen structure of the annulus fibrosus (AF). Recently we reported the use of controlled collagen gel contraction as a vehicle...
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Uniaxial tensile and relaxation tests were carried out on annulus fibrosus samples carved out in the circumferential direction. Images were shot perpendicularly to the loading direction. Digital image correlation techniques accurately measured the evolution of full displacement fields in both transverse directions: plane of fibres and plane of lamellae. In the fibre plane, strains were governed...
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INTRODUCTION Engineering functional replacements for the annulus fibrosus (AF) is contingent upon successful replication of anatomic form and mechanical function. Recently, our group and others have demonstrated the utility of electrospun scaffolds for AF tissue engineering [1]. These ordered, nanofibrous scaffolds direct cell alignment and deposition of a functional fibrocartilage matrix [1]. ...
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A complete thermo-hydro-mechanical model is presented to tackle the complex coupling problems encountered in clay barriers. A detailed formulation coupling the heat, moisture (liquid water and water vapour) and, air transfer in a deformable unsaturated soil is given. The formulation of the AlonsoGens’s mechanical model for unsaturated soil is also incorporated. The sensitivity to some parameter...
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ژورنال
عنوان ژورنال: Journal of Biomechanics
سال: 2012
ISSN: 0021-9290
DOI: 10.1016/s0021-9290(12)70156-2